Lrp4 is required for Extracellular Matrix Production during Chondrogenesis
نویسندگان
چکیده
Introduction: Endochondral ossification is one of the essential processes during skeletal bone system development, which requires chondrogenesis accompanies with proper extracellular matrix production. Recently, regulation of chondrogenesis by Wnt signaling has been extensively studied and some of Wnt signaling components are known to regulate endochondral ossification [1]. However, the underlying molecular mechanisms and the responsible factors are not fully elucidated in the processes. Low-density lipoprotein receptor-related protein 4 (LRP4) is a single-pass transmembrane proteins and has been known to have an antagonistic effect on Wnt signaling. In Wnt signaling, LRP4 is known to function with Dkk1 and SOST, known regulators for bone diseases [2]. However few studies investigated the role of LRP4 on chondrogenesis for endochodral ossification. The present study was designed to explore the function of LRP4 on extracellular matrix production and chondrogenesis via Wnt signaling.
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